The purpose of this paper is to revisit the design of three steps in the freeze-drying process: freezing, primary drying, and secondary drying. Specifically, it provides up-to-date recommendations…
A recent Purdue Today article, accessible here, highlights the synergy between Purdue's prominent expertise in pharmaceutical manufacturing research and education and Ireland's strong pharmaceutical manufacturing sector. The two entities are continually enhancing their collaborative research efforts and expanding study abroad opportunities. The article details the American Irish Medical Summit held in Dublin this August, which was attended by Purdue University representatives. Hosted by the Royal College of Surgeons in Ireland, AIMS serves as a consortium of academic, government, and industry leaders dedicated to advancing health technologies, fostering research and academic partnerships, and developing leadership within…
The article, featured in Purdue Today, describes a grant that was received to expand RF project ongoing in the LyoHUB demonstration facility. Dr. Alexeenko (Co-Director of LyoHUB), Drew Strongrich and other collaborators are…
Summer 2023 brought together lyophilization experts and students to the 2023 Freeze Dry Conference in Breckenridge, Colorado. LyoHUB was well represented at the conference, as not only an…
June, 2023 The Recommended Best Practices in Freeze Dryer Equipment Performance Qualification 2022 paper has been made available in open source by LyoHUB and can be downloaded at no cost. It has already been…
The 2023 LyoHUB Annual Report is now available for download at Pharmahub - Resources: LyoHUB 2023 Annual Report: About and features: Updated yearly FDA-Approved Lyophilized Drugs by Indication Project Reports LyoHUB…
LyoHUB was thrilled to return to the Big Ten Conference Center in Chicago for the LyoHUB Annual Meeting. Engaging discussions and ideas surrounded special talks focused on Industry 4.0 for Lyophilization: Digital…
Just released and available for download! Best Practices and Guidelines (2022) for Scale Up and Technology Transfer in Freeze-Drying Based on Case Studies. Part 2: Past Practices, Current Best…
A big welcome to LyoHUB's newest member, Tempris! Tempris is a developer and manufacturer of the wireless and battery-free temperature measurement systems. These systems are used for…
Welcome to new members, Regeneron! Great to have you as a member of LyoHUB!
Physical Sciences Inc (PSI) joined the LyoHUB family in September 2022. Headquartered in Andover, MA, PSI’s mission is to translate science into solutions that solve mission critical needs…
In August, 2022, Metrohm became the 27th member to join LyoHUB. Metrohm, an international producer of precision instruments for chemical analysis, will add its expertise in Karl Fischer, an instrument used to measure water in samples, and…
A new user-friendly lyophilization simulation and process optimization tool, LyoPRONTO, is now freely available in open source at lyopronto.org. This tool includes freezing, primary drying modeling…
In April 2022, Purdue University/LyoHUB received a NIST Advanced Manufacturing Technology Roadmap Program (MFGTech) award to develop Lyophilization, Freeze-Thaw and Aseptic Drying Technology Roadmap for Pharma/Biotech Manufacturing. The roadmap will expand the 2017 LyoHUB technology roadmap to include novel freeze-drying, aseptic drying and freeze-thaw technologies and address new product modalities including cell and gene therapies, nucleotides (DNA, RNA) vaccines and therapeutics. “The new project will build…
Recommended best practices in monitoring of product status during pharmaceutical freeze drying are presented focusing on methods that apply to both laboratory and production scale. In 2021,…
Thirty-six participants representing over 11 organizations gathered at Purdue University in August, 2022 to receive and introduction to lyophilization, followed by training in quality attributes,…
In 2021, LyoHUB’s Recommended Best Practices for Lyophilization Validation, Parts 1 & 2 outlines best practices for lyophilization process validation and have been published in AAPS…
Thank you to all of our super LyoHUB members who attended the LyoHUB Annual Meeting at Purdue University! It was a productive meeting, and we are grateful for your participation!
A big welcome to the newest member of LyoHUB, Physical Sciences, Inc., a company that translates science into solutions that solve mission critical needs for their customers Physical Sciences Inc.
In a two-year technology roadmapping process, LyoHUB identified an unmet need for online educational programs in pharmaceutical lyophilization. In order to meet this need, LyoHUB has awarded a grant…
LyoHUB is thrilled to welcome Metrohm, USA, a manufacturer of high-precision instruments for chemical analysis, as a member! We look forward to great progress through collaboration!
NIST Awards Funding to Strengthen Advanced Manufacturing for Microelectronics, Digital and Biomanufacturing With funding from the NIST MfgTech program, the existing Advanced Lyophilization Technology Hub, or LyoHub, consortium technology roadmap, which was first published in 2017, will be expanded to include new…
Purdue/LyoHUB team receives a NIIMBL American Rescue Plan award: Advanced Characterization and Manufacturing for mRNA Vaccines Lead Organization: Purdue University, PI: Eric Munson. The goal of this project is to accelerate and support mRNA vaccine production using advanced analytical and manufacturing…
The laboratory of Professor Elizabeth Topp, Professor of Industrial and Physical Pharmacy, Purdue University has an immediate opening for a talented and motivated postdoctoral fellow. The…
As a gift to you, the talented Elizabeth Topp has written a charming and fun story, "mRNA at the Ballet". We hope you enjoy it! We wish you only the best and look forward to the amazing Lyo feats and discoveries as we work together…
"Recommended Best Practices for Lyophilization Validation – 2021 Part II: Process Qualification and Continued Process Verification” was accepted for publication by AAPS…
LyoHUB Publishes "Recommended Best Practices for Lyophilization Validation – 2021, Part II: Process Qualification and Continued Process Verification”. Link coming soon
LyoHUB publishes "Recommended Best Practices for Lyophilization Validation – 2021 Part I: Process Design and Modeling". Click here to go directly to the paper https://link.springer.com/article/10.1208/s12249-021-02086-8
Welcome new member, Jazz Pharmaceuticals
Welcome to new member, Elanco
LyoHUB leads way in first accepted ASTM consensus standard for freeze drying, E3250-21Standard Practice for Product Temperature and Equipment Pressure Instrumentation in Pharmaceutical Freeze Drying.…
Welcome to new member, FujiFilm! Virtual Annual Meeting will be held on April 30. Call information available in members-only area of this site.
LyoHUB Annual Meeting for Members only will be held on Friday, April 30, 2021 virtually.
LyoHUB Co-Director, Dr. Elizabeth Topp leads effort to develop a new drug form may help treat osteoporosis, calcium-related disorders Purdue University innovators developed a stabilized form of human calcitonin, which is a peptide drug already…
Happy Holidays from LyoHUB
LyoHUB's Andrew Strongrich, PhD Candidate at Purdue University will present "Next-Generation Process Monitoring in Lyophilization – Applications for Wireless Sensor Technology," on Thursday, November 19 at 10am and 2pm (EST). Click here to reserve your spot for this free webinar, visit: https://spscie…
LyoHUB now has a YouTube Channel. Subscribe to see all of our latest videos!
Welcome to LyoHUB's newest member, SANOFI! We are glad to have you on board!
LyoHUB offers a FREE, OPEN SOURCE, SELF-PACED Online Lyophilization 101 Short Course. Start today by visiting https://pharmahub.org/courses/lyo101 This 8-module course will introduce participants to Lyophilization. This course also includes a lab exercise. A self-assessment is available after each module.…
Great article updating the public on what is new at LyoHUB https://www.purdue.edu/newsroom/purduetoday/releases/2020/Q2/lyohub-adds-new-course-in-freeze-drying-to-resources-that-can-assist-covid…
Learn about the Importance of Lyophilization for Cancer Therapy for LyoHUB Co-Director, Elizabeth Topp HERE
Analytical Approach to Health Care Delivery course: Purdue University is offering a new series of three online engineering courses to students aspiring to a career in the health care industry…
LyoHUB's Annual Report for 2020 is now available to download online. Click here to download.
LyoHUB is pleased to welcome its newest member, Corning!
LyoHUB's Annual Member Meeting will NOT be held in Chicago. It will be conducted in a series of Webex calls. Please contact Jen Gray to get an invitation to participate in…
Welcome to new member, Sanofi!
LyoHUB's Annual Member Meeting will be held on April 8, 2020 at the Big Ten Conference Center in Chicago and along with year in review and new business, will feature Industry 4.0 for…
LyoHUB is proud to welcome its newest member, Cook Biotech!
Happy Holidays from LyoHUB!
Excellent LyoHUB meeting at NIST! Thank you to all of the speakers, panelists and participants! Presentations included: •Use of Modeling and Simulation in Drug/Device Development and Regulatory Evaluation…
Registration now open for LyoHUB's Lyo Summer School: Lyo201: #Characterization of #Lyophilized Solids July 10 & 11 at Purdue featuring training on #ssHDX-MS, Solid State #NMR, Lyo PRONTO, and more. Register by July 1, 2019 at http://conf.purdue.edu/lyosummer
NSF grant could help enable 'self driving' pharmaceutical lyophilizers. A $750,000 National Science Foundation grant aims to develop real-time sensor technologies, computational modeling…
LyoHUB celebrates its 5th Anniversary at its Annual Meeting in Chicago!
NOW AVAILABLE! Fundamentals of Freeze Drying presented by Steve Nail, Senior Research Scientist, Baxter Biopharma - (5) modules covering Process Overview, Freezing Process, Primary &…
Changing Perceptions: An Understanding of #lyophilization Advancements - interesting article in Pharmaceutical Technology with quotes from Elizabeth Topp at Purdue Industrial and Physical…
Hope that you will join us at the upcoming Gordon Conference being held in New Hampshire from June 9-14, 2019. Liz Topp of LyoHUB and Karthik Nagapudi of Genentech are the conference chairs. The…
LyoHUB is delighted to welcome its 19th member, Greene Tweed, a manufacturer of high-performance elastomers. To learn more about Greene Tweed, click on the logo below
We are pleased to announce the keynote speaker for the 2018 LyoHUB/ASTM Workshop on Pharmaceutical Manufacturing Research and Lyophilization, Joan Byrne, Vice President Science and Technology -…
High Performance Water Recycling system for Space Exploration uses freeze dry (lyophilization) process for transport and reactivation of bacteria. LyoHUB worked with Pancopia on this…
Registration is now open for the ASTM E66 meeting and LyoHUB Workshop on Pharmaceutical Lyophilization to be held on October 23, 2018 at Purdue University, West Lafayette, Indiana. Click HERE to register or visit https://www.astm.org/MEETINGS/filtrexx40.cgi?+-P+MAINCOMM+E55+futuremeetings_maincomm…
LyoHUB will be hosting the ASTM E55 (https://www.astm.org/COMMITTEE/E55.htm) workshop on Pharmaceutical Lyophilization on Tuesday, October 23, 2018 at Purdue University.
LyoHUB is thrilled to welcome new members, OPTIMA Pharma and AMGEN! Learn about each of these companies by clicking on their name!
Congratulations Dr. Elizabeth Topp, recipient of the 2018 Chaney Faculty Scholar award. This award is the highest research award given to faculty by the Purdue College of Pharmacy. The award…
Welcome to our newest member, Abbott! Click on the logo below for more information about Abbott!
"Purdue-based consortium works on improving freeze-drying technology" https://www.purdueexponent.org/campus/article_a59273fd-2d22-5af5-826e-aa463a1b53c8.html
"Purdue research hub to transform freeze drying process used to make lifesaving drugs, preserve food" Read all about it at http://www.purdue.edu/newsroom/releases/2018/Q1/purdue-research-hub-to-transform-freeze-drying-process-used-to-make-lifesaving-drugs,-preserve-food.html
McCrone's Hooke College to offer Freeze Drying course in April 2018. For all of the information about this course, visit https://www.mccrone.com/Lyophilization-Practical-Applications
Read this great article about LyoHUB from The Medicine Maker.
Welcome to LyoHUB's newest member, Bristol-Myers Squibb. Learn more about their successes and innovations at https://www.bms.com/
Learn more about IN-MaC and discover how LyoHUB and IN-MaC can work together to help your Indiana SME. Contact Jen at lyohubinfo@gmail.com to receive more information and schedule a meeting.
LyoHUB is in the news! Dr. Liz Topp speaks about LyoHUB technology roadmap on Inside Indiana
TODAY'S THE DAY! Release day for the LyoHUB Lyophilization Technology Roadmap! To Download it directly, click on the roadmap below Read the article from Purdue Today here. View the video HERE!
A Lyo101 course was offered last week by LyoHUB featured a full 2 ½ days of training with some classroom, but primarily hands-on lab experience under the able instruction of Drs. Nail,…
WELCOME to LyoHUB's newest member, Fresenius Kabi. To learn about their products, visit https://www.fresenius-kabi.com
LyoHUB welcomes Yasmeen Solano of Cal State LA for a summer internship at the LyoHUB lab this month working on “Effects of Antifreeze Protein on the Crystallization of Common…
LyoHUB's Best Practices Paper, "Recommended Best Practices for Process Monitoring Instrumentation in Pharmaceutical Freeze Drying" has been downloaded over 1,200 times! It can be accessed at http://link.springer.c…
Training Event for LyoHUB members at Purdue in July, 2017 LyoHUB Equipment Training and PLM Software Tutorial July 26-27, 2017 Purdue University Birck Nanotechnology Center Wednesday, July 26, 1-4pm: LyoHUB demonstration facility equipment training Participants will be familiarized with: Lyophilizers Freeze Dry Microscope…
Congratulations to Sajal Patel and his collaborators on the publishing of this Best Practices Paper: Lyophilized Drug Product Cake Appearance: What is Acceptable? This is now available in JPharmSci…
Welcome to the newest member of LyoHUB, Siemens Product Lifecycle Management (PLM) Software. To learn more about this global software company, visit https://www.plm.automation.siemens.com/e…
LyoHUB presented draft of LyoHUB Lyophilization Technology Roadmap at ISL-FD Chicago. Visit this site in July 2017 to download the final copy!
LyoHUB Annual Meeting was held at the McCrone Group headquarters in Illinois.
"The new equation for pharmaceutical lyophilisation". March 9, 2017. Live webinar. Register now! http://bit.ly/2kBj8mt” presented by Purdue & IMA
Dr. Elizabeth Topp is the co-chair for this year's Gordon Research Conference on “Preclinical Form and Formulation for Drug Discovery” will be held June 4-9, 2017 in Stowe,…
LyoHUB Members are invited to call in for presentations by Dr. Celia Cruz “FDA Experience with Continuous Manufacture” and Dr. Maxwell Korang-Yeboah "Office of Testing and…
Thank you to those who stopped by the LyoHUB poster, or referred those who were interested in learning more about LyoHUB. It was a great opportunity and wonderful to catch up with so many members!
Great LyoHUB meeting during PepTalk 2017 today. Wonderful progress was made on the Best Practices paper!
WELCOME to Roche which has joined LyoHUB! To learn more about Roche, visit http://www.roche.com/
WELCOME to McCrone Microscopes & Accessories! To learn more about McCrone, please visit https://www.mccrone.com/instrument-sales
WELCOME to ABBVIE, the newest member of LyoHUB! To learn more about Abbvie, please visit http://www.abbvie.com/
Best Practices Brochure for "Process Instrumentation in Freeze Drying" introduced. Click here to download a copy of the brochure to keep in your lab.
WELCOME! to the newest member of LyoHUB, ALLERGAN! For more information about Allergan, please visit http://www.allergan.com
LyoHUB has strong presence at CPPR Freeze Drying Conference in Breckenridge, CO fro July 12-15, 2016 Dr. Elizabeth Topp presents, "High Resolution Characterization of Proteins in Lyophilized Solids" Dr. Alina Alexeenko…
Methodology of Lyophilizers Characterization to Enable Modeling of Process Parameters During Cycle Scale Up Webinar Date & Time: 6/21/2016 10:00 AM - 3:00 PM ET, Presenter(s): Dr. Serguei Tchessalov Session 1: 6/21/2016 10:00 AM - 11:00 AM ET Session 2: 6/21/2016 2:00 PM - 3:00 PM ET Abstract: Factory acceptance…
Hold the date! We are currently putting together a great event at Purdue University for the fall, in conjunction with the CPPR meeting. Tentative dates are 10/11/16 in the evening with events all day…
Our first Lyo Launch Pad project is complete! Dr David Detwiler of Nanovis Inc worked on lyophilized gelatin sponge for medical applications in the LyoHUB demonstration facility.Nanovis Inc is an…
WELCOME! to the newest member of LyoHUB, SP Scientific! For more information about SP Scientific, please visit http://www.spscientific.com
Please stop by and visit the LyoHUB booth at the ISL-FD Conference in Chicago on April 14, 2016. For more information about the conference, please visit http://islyophilization.org/conference-2016-ch…
LyoHUB will host a dinner and workshop on Wednesday, April 13, 2016 at the Big Ten Headquarters in Rosemont, IL. This event is the evening before the ISL-FD conference begins. For more information on…
WELCOME! to the newest member of LyoHUB, BAXTER! For more information about Baxter, please visit http://www.baxter.com
The LyoHUB Demo Facility is up and running! Please see photos of the facility under the "Demo Facility" tab on this website. For more information about using this facility, please contact…
LyoHUB hosted a Roadmapping Workshop in conjunction with the PepTalk Conference in San Diego on January 20. For more information, click here.
LyoHUB consortium will host Lyophilization Technology Roadmapping workshop on October 6-7, 2015 in West Lafayette, IN. Read more in a story "Purdue to advance freeze-drying technology…
The U.S. Commerce Department’s National Institute of Standards and Technology (NIST) selected Advanced Lyophilization Technology Consortium LyoHUB as one of 16 awards totaling $7.8 million…
Liz Topp's group at Purdue publishes a video tutorial on high-resolution analytical methods for lyophilized proteins. "Mass Spectrometric Approaches to Study Protein Structure and Interactions in Lyophilized Powders" J Vis Exp. 2015; (98): 52503. Published online 2015…