Advanced Lyophilization Technology Hub an industry-led partnership to advance the science and technology of lyophilization/freeze-drying. 

The goal of Advanced Lyophilization Technology Hub (LyoHUB) is to advance the science and technology of freeze-drying/lyophilization. LyoHUB’s members include companies in the pharmaceutical and food processing sectors, equipment manufacturers and university researchers, who combine their expertise and resources to accomplish the goal. Immediate objectives are:  (i) to identify and disseminate Best Practices for lyophilization equipment performance, testing and validation and (ii) to conduct applied research to advance lyophilization processes and products. 



What's Happening


  • LyoHUB offers NEW Short Course on Pharmaceutical Freeze Drying, “Freeze Drying: Principles and Practice

    The curriculum for this new course was designed by Dr. Steven Nail and Drew Strongrich, Research Scientist at LyoHUB.

    Following completion of the "Freeze Drying: Principals and Practice" course, students will be able to:

    • Identify and describe the three fundamental phases of the freeze-drying process.
    • Outline key unit operations, processes, equipment, and process monitoring methods associated with the lyophilization of parenteral products.
    • Describe product critical quality attributes, how they are measured, and the roles they play in short and long-term stability.
    • Provide a broad overview of an approach to developing and optimizing a freeze-drying process, including the use of mathematical models for common formulations and containers.
    • Discuss common deficiencies in the development and manufacturing of freeze-dried pharmaceuticals and provide information on current best-practices in industry.

    Continuing Education Credit Available.

    For more information and enrollment, visit


Spotlights Archive


July 19, 2024

Residual gas analysis (RGA) can be used in pharmaceutical manufacturing to achieve a more comprehensive understanding of the freeze-drying process. RGA provides real-time insights into key variables, including leak detection and monitoring contaminants. For more on RGA in pharmaceutical lyophilization and experimental data from the LyoHUB demonstration facility, download the App Note prepared in partnership with innovative instrument provider, INFICON

Stay tuned for more updates

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