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Tools and Educational Presentations

Interactive online tools:

for modeling and analysis of lyophilization/freeze-drying:

1. Interactive Lyocalculator 


Lyocalculator models product temperature and sublimation rate during primary drying for specified chamber pressure, shelf temperature and container/product properties. 


Excel-based lyocalculator (Courtesy Dr. Serguei Tchessalov/Pfizer): Lyocycle_design_and_transfer_template_Breckenridge_workshop--Pfizer_Original.xls (2 MB)


Abridged version for training by Dr. Tong Zhu: 170727-Lyo-Calculator_Training-Added_Macro_Solver.xls (66 KB

2. Pressure Variation Calculator

Lyo Chamber Pressure Variation Calculator 

simulate variation of pressure within product chamber for specified chamber pressure, shelf size and drying rate rate. 


Best Practices Papers:

1) LyoHUB's Best Practices Paper, "Recommended Best Practices for Process Monitoring Instrumentation in Pharmaceutical Freeze Drying"   can be accessed at


1. Developing Transferable Freeze Drying Protocols Using Accuflux® and a MicroFD®

Authors: TN Thompson (Millrock Technology, Inc.), Quiming Wang (Millrock Technology, Inc.), Cindy Reiter (Millrock Technology, Inc.)

FDProtocols.pdf (4 MB) narrated presentation: