for modeling and analysis of lyophilization/freeze-drying:
Lyocalculator models product temperature and sublimation rate during primary drying for specified chamber pressure, shelf temperature and container/product properties.
Excel-based lyocalculator (Courtesy Dr. Serguei Tchessalov/Pfizer): Lyocycle_design_and_transfer_template_Breckenridge_workshop--Pfizer_Original.xls (2 MB)
Abridged version for training by Dr. Tong Zhu: 170727-Lyo-Calculator_Training-Added_Macro_Solver.xls (66 KB)
simulate variation of pressure within product chamber for specified chamber pressure, shelf size and drying rate rate.
1. Developing Transferable Freeze Drying Protocols Using Accuflux® and a MicroFD®
Authors: TN Thompson (Millrock Technology, Inc.), Quiming Wang (Millrock Technology, Inc.), Cindy Reiter (Millrock Technology, Inc.)