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Predict product temperature during primary drying
Version 2.0 - published on 11 May 2018
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Predicts product temperature during primary freeze-drying based on pseudo steady-state heat and mass transfer model.
Fill volume Solids concentration Shelf heat transfer coefficient parameters: Kv=Kc+Kp*Pc/(1+KD*Pc), where Pc is the chamber pressure Cross sectional area of the product in the vial Vial area calculated based on outside diameter Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thickness of dry layer at any time Shelf temperature Chamber pressure OUTPUT: Temperature versus time chart
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