LyoHUB offers a new lyophilization process optimization tool, LyoPRONTO, in open source

A new user-friendly lyophilization simulation and process optimization tool, LyoPRONTO, is now freely available in open source at This tool includes freezing, primary drying modeling and optimization modules as well as a design space generator. It can be used to model the lyophilization process and create more efficient cycles. Moreover, the tool is capable of determining the vial heat transfer parameters and product resistance characteristics, thus reducing the number of experiments.

The 0D lumped capacitance modeling approach is used in a freezing calculator to predict the product temperature variation with time and results in reasonably good agreement with experimental measurements. The primary drying calculator is based on 1D heat and mass transfer analysis in a vial and deviation from the experimental data is within 3%.