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  1. Information Representation in POPE

    23 Jan 2008 | Online Presentations | Contributor(s): venkat, laelaf, Rex Reklaitis, pradeepsuresh

    The development of a pharmaceutical product requires the collection of information during pre-formulation studies, product formulation, process development, scaleup and manufacturing. A large amount of information of different types, ranging from raw data to lab reports to sophisticated math...

  2. Navigating the POPE Ontology

    21 Jan 2008 | Publications | Contributor(s): laelaf, venkat

    What knowledge is included in POPE? There are three knowledge components: guideline knowledge, mathematical knowledge and information representations. The guideline knowledge component includes representations of actions and decisions. The mathematical knowledge component includes descriptions of...

  3. Purdue Ontology for Pharmaceutical Engineering

    21 Jan 2008 | Series | Contributor(s): laelaf, venkat, shsu, pradeepsuresh

    Web Ontology Language (OWL), recommended by and based from Resource Description Framework (W3C), is used to define ontologies. OWL uses XML syntax to express semantics. OWL can formalize a domain by defining classes, properties of these classes, and relations between them. OWL can also define...

  4. Ontological informatics infrastructure for pharmaceutical product development

    17 Jan 2008 | Publications | Contributor(s): venkat, Rex Reklaitis, laelaf, pradeepsuresh

    Informatics infrastructure plays a crucial role in supporting different decision making activities related to pharmaceutical product development, pilot plant and commercial scale manufacturing by streamlining information gathering, data integration, model development and managing all these for...

  5. Towards intelligent decision support for pharmaceutical product development

    17 Jan 2008 | Publications | Contributor(s): venkat, Rex Reklaitis, laelaf, pradeepsuresh

    Developing pharmaceutical product formulation in a timely manner and ensuring quality is a complex process that requires a systematic, science-based approach. Information from various categories, including properties of the drug substance and excipients, interactions between materials, unit...

  6. Roller Compactor

    02 Jan 2008 | Tools | Contributor(s): Kamal Kuriyan

    Calculate nip angle, normal and shear stresses for roller compactor using Johanson's model

  7. ParticleVis: A Tool for DEM Particle Visualization

    07 Jan 2008 | Downloads | Contributor(s): Carl Wassgren, Avik Sarkar

    ParticleVis is a visualization tool specialized for loading and exploring particulate simulation data. It contains a set of features that enables powerful and useful visualizations of particle simulations to be quickly generated. Support is provided for visualization of hundreds of thousands of...

  8. Pharmaceutical Informatics

    30 Dec 2007 | Series | Contributor(s): venkat, Rex Reklaitis, laelaf, shsu, pradeepsuresh

    Pharmaceutical products manufacturing is an important growth area for the US economy. Continued progress in biotechnology and genetic engineering coupled with an aging population will create both new mega-opportunities as well as pose new major challenges in this area, where the products are...

  9. Workspace

    18 Dec 2007 | Tools | Contributor(s): Nicholas Kisseberth

    Development workspace

  10. Roughness models for particle adhesion

    20 Dec 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    The effects of different surface roughness models on a previously developed van der Waals adhesion model were examined. The van der Waals adhesion model represented surface roughness with a distribution of asperities. It was found that the constraints used todefine the asperity distribution on...

  11. Particle and Thin Film Adhesion

    20 Dec 2007 | Series | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    The adhesion of micron and sub-micron scale particles to surfaces is of tremendous interest in a wide range of industrial and civilian applications. We measure directly the adhesion of particles to surfaces using atomic force microscopy and develop experimentally-validated, science-based models...

  12. Simulation of the Adhesion of Particles to Surfaces

    20 Dec 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    The removal of micrometer and submicrometer particles fromdielectric and metal films represents a challenge in postchemicalmechanical polishing cleaning. Proper modeling of the adhesiveforce between contaminant particles and these films is needed todevelop optimal solutions to postchemical...

  13. Hamaker Constants in Integrated Circuit Metallization

    20 Dec 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    A new method for determining Hamaker constants was examinedfor materials of interest in integrated circuit manufacture. Anultra-high vacuum atomic force microscope and an atomic force microscopeoperated in a nitrogen environment were used to measurethe interaction forces between metals,...

  14. A Theoretical and Experimental Study of Surface Forces in Adhesion of Particles to Thin Films

    20 Dec 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    The interactions between micron- and nano-particles and rough surfaces are of great importance and have numerous applications in surface science and biotechnology. It is essential to have estimates of surface/intermolecular forces between interacting bodies to describe and to manipulate the...

  15. Hopper Segregation

    18 Dec 2007 | Animations | Contributor(s): Carl Wassgren

    The Particulate Sciences Laboratory at Purdue University investigates the mixing and segregation of binary and multi-component granular materials. Solids mixing, also known as blending, is a common processing operation used in the manufacture of pharmaceutical products. The intent of mixing...

  16. Inter- and Intra- Tablet Coating Variability

    18 Dec 2007 | Animations | Contributor(s): Carl Wassgren

    Tablets are coated for a number of reasons, the most important of which is controlling the release profiles and bioavailability of the active pharmaceutical ingredient. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form.Tablets are usually...

  17. Visualization of Particle-Based Computer Data

    18 Dec 2007 | Series | Contributor(s): Carl Wassgren, Avik Sarkar

    The ParticleVis software system offers full-featured visualization of discrete element method (DEM) computer data for real-time 3D rendering of large sets of particle states. ParticleVis capabilities include:adjustable lighting conditions and camera viewing characteristics,options to display...