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Acidic Hydrolysis of Peptide P60264

By Lee Kirsch, Stephen Dion Stamatis1

1. University of Iowa

Generate simulated degradation data for typical pharmaceutical peptide

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Version 1.2 - published on 23 Jun 2014

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Conduct the appropriate studies to determine the degradation scheme and appropriate rate laws for Peptide P60264 in acidic solutions (pH 0 to 7). All studies are conducted at 70 C. First order kinetics may be assumed. No buffer effects are present (studies are conducted with a pH stat). Concentrations are provided as % of initial starting material. The primary structure (sequence of amino acids) is provided. You may choose starting materials from any of the peptide degradation products. Data can be output in .csv files to be input into EXCEL or other data analysis software.

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Researchers should cite this work as follows:

  • Lee Kirsch; Stephen Dion Stamatis (2014), "Acidic Hydrolysis of Peptide P60264,"

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