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Dose regimen individualization
Dose regimen individualization
Version 1.2 - published on 08 Dec 2011
This tool is closed source.
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Abstract
The optimal dosage regimen for an individual is a combination
of dose amount (Dose) and dosing interval (i.e., time between
doses), which make the drug level remain in the desired
therapeutic window given a target confidence level. The
therapeutic window is defined as the concentration range
which is below a threshold defining an acceptable
risk of toxic side effect (TWU) and above a threshold defining a
minimum acceptable level of efficacy (TWL). This tool determines the feasible dosage range for drugs that can be described using a multidose one-compartment model with first order absorption. It takes as input the desired confidence level and dosing interval, and the probability distribution of PK parameter for the patient under study. The tool provides the possibility of describing this probability distribution by using either a collection of samples or a multivariate Gaussian distribution.
Sponsoredby
Support from the United States National Science Foundation (Grant NSF-CBET-0941302) is gratefully acknowledged.
References
Lainez, J., Blau, G., Mockus, L., Orcun, S., & Reklaitis, G. (2011). Pharmacokinetic Based Design of Individualized Dosage Regimens Using a Bayesian Approach. Industrial and Engineering Chemistry Research , 50, 5114-5130.
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