Collaboration for pharmaceutical engineering and science
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Simulation of the Adhesion of Particles to Surfaces
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02 Jul 2024 | Publications
The removal of micrometer and submicrometer particles fromdielectric and metal films represents a challenge in postchemicalmechanical polishing cleaning. Proper modeling of the adhesiveforce between contaminant particles and these films is needed todevelop optimal solutions to postchemical...
Hamaker Constants in Integrated Circuit Metallization
A new method for determining Hamaker constants was examinedfor materials of interest in integrated circuit manufacture. Anultra-high vacuum atomic force microscope and an atomic force microscopeoperated in a nitrogen environment were used to measurethe interaction forces between metals,...
A Theoretical and Experimental Study of Surface Forces in Adhesion of Particles to Thin Films
The interactions between micron- and nano-particles and rough surfaces are of great importance and have numerous applications in surface science and biotechnology. It is essential to have estimates of surface/intermolecular forces between interacting bodies to describe and to manipulate the...
Hopper Segregation
02 Jul 2024 | Animations
The Particulate Sciences Laboratory at Purdue University investigates the mixing and segregation of binary and multi-component granular materials. Solids mixing, also known as blending, is a common processing operation used in the manufacture of pharmaceutical products. The intent of mixing...
Inter- and Intra- Tablet Coating Variability
Tablets are coated for a number of reasons, the most important of which is controlling the release profiles and bioavailability of the active pharmaceutical ingredient. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form.Tablets are usually...
Visualization of Particle-Based Computer Data
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02 Jul 2024 | Series
The ParticleVis software system offers full-featured visualization of discrete element method (DEM) computer data for real-time 3D rendering of large sets of particle states. ParticleVis capabilities include:adjustable lighting conditions and camera viewing characteristics,options to display...