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Jos Corver lecture on Continuous Freeze Drying

By Jos Corver

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Jos Corver December 2018 lecture on Continuous Freeze Drying for LyoHUB at Purdue University can be viewed at



The guidelines of FDA’s PAT mention the need for continuous processing in pharma to achieve a mechanism of 100% control of process and product quality. Freeze-drying is one of the ‘missing links’ in the chain of pharmaceutical manufacturing. Current Freeze-drying is a very slow process and in order to achieve a continuous process there is a need for drastic increase of process speed. RheaVita developed a route towards such increase and also developed physical prototypes to demonstrate and further develop the scientific background. Throughout the development exercises, a scientific way of working has been adopted involving modeling and experimental verification. From the earlier phases onwards, PAT tools have been developed and employed, finally leading to a concept where all process steps are in closed-loop control. The presentation will illustrate some highlights of this effort which started effectively in 2013.



Ir. Jos Corver: Jos Corver holds a degree in applied physics in the field of rheology and physical transport phenomena. Leading development and engineering work in various industries enriched his expertise in aerodynamics, powder physics, vacuum deposition techniques, material science and NMR. Having had leading roles in industrialization processes he also improved his expertise in project management and quality and statistical assessment including Design of Experiments, Multiple Regression and FMEA. After 12 years within BOC Edwards / IMA Life, he started his own company since 2011, RheaVita. RheaVita strives for innovative improvements in pharmaceutical processing and specifically in freeze drying and the processes supporting this. In parallel he takes project management roles in semiconductor industry to support his desire to implement cross-over between different industrial fields. Jos Corver has published in various areas like pharmaceutical, optical en business literature. He is author of a range of patents on the application of NMR, improvements in freeze drying, color printing and Extreme UV sources.

Jos Corver is member of the Board of Directors of the ISL-FD.


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Researchers should cite this work as follows:

  • Jos Corver (2019), "Jos Corver lecture on Continuous Freeze Drying,"

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