This is one of a set of experiments designed for lower level undergraduate courses. The focus of the experimental set is to introduce pharmaceutical concepts to undergraduates while also incorporating general engineering educational objectives. This contains both a student version and instructor version.
In the experiment, students evaluate the effect of tablet manufacturing process on the rate of reaction. Students compare the effervescent reaction of a whole tablet of Alka-Seltzer® to the initial raw ingredients. These are allowed to react with water, while students take residual mass measurements as time progresses.
The objectives of this experiment are: Students will perform a basic mass balance on an effervescence reaction in pharmacology; Students will conduct theoretical stoichiometric calculations and compare to experimental results; Students will learn about the equilibrium constants and other fundamental aspects of reactions
This experiment (and the others in this set) were developed by Rowan University as part of the NSF-funded Engineering Research Center (ERC) for Structured Organic Particulate Systems (SOPS).
Researchers should cite this work as follows:
Alexander Vincent Jannini; David J Krause; Heather Malino; Kevin Sweeney; C.S. Slater PhD; M.J. Savelski PhD (2014), "Effervescence Laboratory - Student and Instructor's Version," https://pharmahub.org/resources/623.