You are here: resources › Tools › Alkaline Penicillin G Hydrolysis › About

Alkaline Penicillin G Hydrolysis

By Lee Kirsch, Stephen Dion Stamatis1

1. University of Iowa

Simulate hydrolysis of penicillin G

Launch Tool

This tool version is unpublished and cannot be run. If you would like to have this version staged, you can put a request through HUB Support.

Archive Version 1.0
Published on 16 Oct 2013
Latest version: 1.2. All versions

This tool is closed source.

Category

Tools

Published on

Abstract

Study penicillin G hydrolysis in aqueous solutions at 30 C in the presence of various amine, hydroxyl and sulfhydryl buffer systems. Choose the buffer and the concentrations of the acidid and basic forms of the buffer. The pH will be determined based on your choices. Choose time points for sampling the substrate and a product (penicilloic acid). Simulate the degradation study and use the resultant concentration time profiles to determine the reaction scheme and rate laws. Use this information to propose mechanisms for individual reaction pathways. Simulated data (contains error) can be output to .csv files and then used with your favorite plotting and analysis softward.

Cite this work

Researchers should cite this work as follows:

  • Lee Kirsch; Stephen Dion Stamatis (2014), "Alkaline Penicillin G Hydrolysis," https://pharmahub.org/resources/kwpeng.

    BibTex | EndNote