You are here: resourcesToolsDose regimen individualizationAbout

Dose regimen individualization

By Jose Miguel Lainez, Linas Mockus1, Gary Blau1, Seza Orcun, Rex Reklaitis1

1. Purdue University

Dose regimen individualization

Launch Tool

This tool version is unpublished and cannot be run. If you would like to have this version staged, you can put a request through HUB Support.

Archive Version 1.1
Published on 27 Jan 2014
Latest version: 1.2. All versions

This tool is closed source.

Category

Tools

Abstract

The optimal dosage regimen for an individual is a combination of dose amount (Dose) and dosing interval (i.e., time between doses), which make the drug level remain in the desired therapeutic window given a target confidence level. The therapeutic window is defined as the concentration range which is below a threshold defining an acceptable risk of toxic side effect (TWU) and above a threshold defining a minimum acceptable level of efficacy (TWL). This tool determines the feasible dosage range for drugs that can be described using a multidose one-compartment model with first order absorption. It takes as input the desired confidence level and dosing interval, and the probability distribution of PK parameter for the patient under study. The tool provides the possibility of describing this probability distribution by using either a collection of samples or a multivariate Gaussian distribution.

Sponsoredby

Support from the United States National Science Foundation (Grant NSF-CBET-0941302) is gratefully acknowledged.

References

Lainez, J., Blau, G., Mockus, L., Orcun, S., & Reklaitis, G. (2011). Pharmacokinetic Based Design of Individualized Dosage Regimens Using a Bayesian Approach. Industrial and Engineering Chemistry Research , 50, 5114-5130.

Cite this work

Researchers should cite this work as follows:

  • Jose Miguel Lainez; Linas Mockus; Gary Blau; Seza Orcun; Rex Reklaitis (2024), "Dose regimen individualization," https://pharmahub.org/resources/doseregimen.

    BibTex | EndNote

Tags