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Lyo Calculator

By Linas Mockus

Predict product temperature during primary drying

Launch Tool

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Archive Version 1.0
Published on 22 Apr 2010
Latest version: 2.0. All versions

Open source: license | code unavailable



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Predicts product temperature at the sublimation interface based on pseudo steady-state heat and mass transfer model

Fill volume (mL)
Solids concentration (g/g)
Shelf heat transfer coefficient (cal/s/cm2/C)
Cross sectional area of the product in the vial (cm2)
Vial area calculated based on outside diameter (cm2)
Dry layer area normalized mass transfer resistance parameters: Rphat = R0 + A1 * l / (1 + A2 * l), where l is thickness of dry layer at any time (Torr*cm2*ht/g)
Shelf temperature (K)
Chamber pressure (Torr)

Temperature versus time chart


M.J. Pikal Excel based Lyo Calculator


M.J. Pikal, Use of Laboratory Data in Freeze Drying Process Design: Heat and Mass Transfer Coefficients and the Computer Simulation of Freeze Drying

Cite this work

Researchers should cite this work as follows:

  • Linas Mockus (2018), "Lyo Calculator,"

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