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Lyo Calculator
Predict product temperature during primary drying
Launch Tool
Archive Version 1.0
Published on 22 Apr 2010
Latest version: 2.0. All versions
Open source: license | code unavailable
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Abstract
Predicts product temperature at the sublimation interface based on pseudo steady-state heat and mass transfer model
INPUT PARAMETERS:
Fill volume (mL)
Solids concentration (g/g)
Shelf heat transfer coefficient (cal/s/cm2/C)
Cross sectional area of the product in the vial (cm2)
Vial area calculated based on outside diameter (cm2)
Dry layer area normalized mass transfer resistance parameters: Rphat = R0 + A1 * l / (1 + A2 * l), where l is thickness of dry layer at any time (Torr*cm2*ht/g)
Shelf temperature (K)
Chamber pressure (Torr)
OUTPUT:
Temperature versus time chart
INPUT PARAMETERS:
Fill volume (mL)
Solids concentration (g/g)
Shelf heat transfer coefficient (cal/s/cm2/C)
Cross sectional area of the product in the vial (cm2)
Vial area calculated based on outside diameter (cm2)
Dry layer area normalized mass transfer resistance parameters: Rphat = R0 + A1 * l / (1 + A2 * l), where l is thickness of dry layer at any time (Torr*cm2*ht/g)
Shelf temperature (K)
Chamber pressure (Torr)
OUTPUT:
Temperature versus time chart
Credits
M.J. Pikal Excel based Lyo Calculator
References
M.J. Pikal, Use of Laboratory Data in Freeze Drying Process Design: Heat and Mass Transfer Coefficients and the Computer Simulation of Freeze Drying
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