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By Stan Karpuk1, Gayathri Shivkumar, Linas Mockus1, Alina Alexeenko1

1. Purdue University

Predict product temperature during primary drying

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Version 2.0 - published on 11 May 2018

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Predicts product temperature during primary freeze-drying based on pseudo steady-state heat and mass transfer model. 

Fill volume Solids concentration Shelf heat transfer coefficient parameters: Kv=Kc+Kp*Pc/(1+KD*Pc), where Pc is the chamber pressure Cross sectional area of the product in the vial Vial area calculated based on outside diameter Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thickness of dry layer at any time Shelf temperature Chamber pressure OUTPUT: Temperature versus time chart

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Researchers should cite this work as follows:

  • Stan Karpuk; Gayathri Shivkumar; Linas Mockus; Alina Alexeenko (2018), "LyoCalculator,"

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