Predicts product temperature during primary freeze-drying based on pseudo steady-state heat and mass transfer model. 

INPUT PARAMETERS:
Fill volume Solids concentration Shelf heat transfer coefficient parameters: Kv=Kc+Kp*Pc/(1+KD*Pc), where Pc is the chamber pressure Cross sectional area of the product in the vial Vial area calculated based on outside diameter Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thickness of dry layer at any time Shelf temperature Chamber pressure OUTPUT: Temperature versus time chart

Researchers should cite this work as follows:

• Stan Karpuk; Gayathri Shivkumar; Linas Mockus; Alina Alexeenko (2018), "LyoCalculator," https://pharmahub.org/resources/lyocalculator.

  BibTex | EndNote

1. freeze-drying
2. Heat and mass transfer
3. lyo
4. lyocalculator
5. Lyophilization
6. Primary drying