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  Malegra 120 typically starts working within 30 to 60 minutes after ingestion. However, individual response times may vary based on factors such as metabolism and the presence of food in the stomach.  Malegra 120 is a higher-dose medication for treating ED, offering a relatively rapid onset of action and a duration of effect that allows for improved sexual performance during the specified time frame. However, it's important to use this medication under medical supervision to ensure safety and efficacy.