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Level Set Dissolution

By Dan Braido1, Alberto Cuitino1, Ann Christine Catlin2

1. Rutgers University 2. Purdue University

Level Set Dissolution Description

Launch Tool

This tool version is unpublished and cannot be run. If you would like to have this version staged, you can put a request through HUB Support.

Archive Version 1.1
Published on 02 Feb 2014
Latest version: 1.2. All versions

This tool is closed source.

Category

Tools

Published on

Abstract

This tool takes a set of user defined parameters to build a model tablet and then simulate its dissolution. The simulation is based on several levels of tablet fluid interaction. This is accomplished via a series of equations which describe the surface erosion, solvent penetration, particle dissolution and solute diffusion. These equations are mostly based on a modified version of Fick's second law and are calculated using a finite-differencing scheme. The simulation space is mapped using a fixed cartesian mesh. The location of the tablets surface is tracked using a level set approach. The proper boundary conditions are applied to the diffusion equations using a concentration ghosting method. cylinder

Credits

Dan Braido Alberto Cuitino

Cite this work

Researchers should cite this work as follows:

  • Dan Braido; Alberto Cuitino; Ann Christine Catlin (2014), "Level Set Dissolution," https://pharmahub.org/resources/levsetdissol.

    BibTex | EndNote

Tags

  1. Disintegration
  2. Dissolution
  3. Finite differencing
  4. Level sets