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Level Set Dissolution

By Dan Braido1, Alberto Cuitino1, Ann Christine Catlin2

1. Rutgers University 2. Purdue University

Level Set Dissolution Description

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Version 1.2 - published on 06 Jun 2014

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Abstract

This tool takes a set of user defined parameters to build a model tablet and then simulate its dissolution. The simulation is based on several levels of tablet fluid interaction. This is accomplished via a series of equations which describe the surface erosion, solvent penetration, particle dissolution and solute diffusion. These equations are mostly based on a modified version of Fick's second law and are calculated using a finite-differencing scheme. The simulation space is mapped using a fixed cartesian mesh. The location of the tablets surface is tracked using a level set approach. The proper boundary conditions are applied to the diffusion equations using a concentration ghosting method. cylinder

Credits

Dan Braido Alberto Cuitino

Cite this work

Researchers should cite this work as follows:

  • Dan Braido; Alberto Cuitino; Ann Christine Catlin (2014), "Level Set Dissolution," https://pharmahub.org/resources/levsetdissol.

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Tags

  1. Disintegration
  2. Dissolution
  3. Finite differencing
  4. Level sets