You are here: resourcesToolsLyo CalculatorAbout

Lyo Calculator

By Linas Mockus

Purdue University

Predict product temperature during primary drying

Launch Tool

You must login before you can run this tool.

Version 1.0 - published on 22 Apr 2010

Open source: license | download

View All Supporting Documents

See also

No results found.

Category Tools
Abstract Predicts product temperature at the sublimation interface based on pseudo steady-state heat and mass transfer model

INPUT PARAMETERS:
Fill volume (mL)
Solids concentration (g/g)
Shelf heat transfer coefficient (cal/s/cm2/C)
Cross sectional area of the product in the vial (cm2)
Vial area calculated based on outside diameter (cm2)
Dry layer area normalized mass transfer resistance parameters: Rphat = R0 + A1 * l / (1 + A2 * l), where l is thickness of dry layer at any time (Torr*cm2*ht/g)
Shelf temperature (K)
Chamber pressure (Torr)

OUTPUT:
Temperature versus time chart
Cite this work

Researchers should cite this work as follows:

  • Linas Mockus (2010), "Lyo Calculator," http://pharmahub.org/resources/lyocalculator.

    BibTex | EndNote

Tags
  1. Heat and mass transfer 1
  2. Lyophilization 1
  3. Primary drying 1