Visualization of Particle-Based Computer Data

18 Dec. 2007 | Series | Contributor(s): Carl Wassgren, Avik Sarkar

The ParticleVis software system offers full-featured visualization of discrete element method (DEM) computer data for real-time 3D rendering of large sets of particle states. ParticleVis capabilities include: adjustable lighting conditions and camera viewing characteristics, options to display …

Workspace

18 Dec. 2007 | Tools | Contributor(s): Nicholas Kisseberth

Linux desktop running in your web browser

Inter- and Intra- Tablet Coating Variability

18 Dec. 2007 | Animations | Contributor(s): Carl Wassgren

Tablets are coated for a number of reasons, the most important of which is controlling the release profiles and bioavailability of the active pharmaceutical ingredient. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form. Tablets are usually …

Hopper Segregation

18 Dec. 2007 | Animations | Contributor(s): Carl Wassgren

The Particulate Sciences Laboratory at Purdue University investigates the mixing and segregation of binary and multi-component granular materials. Solids mixing, also known as blending, is a common processing operation used in the manufacture of pharmaceutical products. The intent of mixing …

Simulation of the Adhesion of Particles to Surfaces

20 Dec. 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

The removal of micrometer and submicrometer particles from dielectric and metal films represents a challenge in postchemical mechanical polishing cleaning. Proper modeling of the adhesive force between contaminant particles and these films is needed to develop optimal solutions to postchemical …

Hamaker Constants in Integrated Circuit Metallization

20 Dec. 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

A new method for determining Hamaker constants was examined for materials of interest in integrated circuit manufacture. An ultra-high vacuum atomic force microscope and an atomic force microscope operated in a nitrogen environment were used to measure the interaction forces between metals, …

A Theoretical and Experimental Study of Surface Forces in Adhesion of Particles to Thin Films

20 Dec. 2007 | Teaching Materials | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

The interactions between micron- and nano-particles and rough surfaces are of great importance and have numerous applications in surface science and biotechnology. It is essential to have estimates of surface/intermolecular forces between interacting bodies to describe and to manipulate the nature …

Ontological Informatics Infrastructure: An Overview

23 Jan. 2008 | Online Presentations | Contributor(s): Venkat Venkatasubramanian, Rex Reklaitis, Leaelaf Hailemariam, Pradeep Suresh

Pharmaceutical product development involves managing a large amount of information and knowledge in different formats. Ontological informatics is used to represent and integrate the information and knowledge and support product development applications.Venkat Venkatasubramanian,Chunhua Zhao, Girish …

Discrete Element Method (DEM) Course Module

26 Jan. 2008 | Courses | Contributor(s): Carl Wassgren, Avik Sarkar

The DEM course module was created by Carl Wassgren of the Particulate Systems Laboratory (PSL) at Purdue University. The series consists of slides and videos that will familiarize you with the basics of DEM. Discrete Element Method has been applied to analyze and predict flow behaviour in a wide …

Roughness models for particle adhesion

20 Dec. 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

The effects of different surface roughness models on a previously developed van der Waals adhesion model were examined. The van der Waals adhesion model represented surface roughness with a distribution of asperities. It was found that the constraints used to define the asperity distribution on …

Particle and Thin Film Adhesion

20 Dec. 2007 | Series | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

The adhesion of micron and sub-micron scale particles to surfaces is of tremendous interest in a wide range of industrial and civilian applications. We measure directly the adhesion of particles to surfaces using atomic force microscopy and develop experimentally-validated, science-based models for …

Pharmaceutical Informatics

29 Dec. 2007 | Series | Contributor(s): Venkat Venkatasubramanian, Rex Reklaitis, Leaelaf Hailemariam, Shuo-Huan Hsu, Pradeep Suresh

Pharmaceutical products manufacturing is an important growth area for the US economy. Continued progress in biotechnology and genetic engineering coupled with an aging population will create both new mega-opportunities as well as pose new major challenges in this area, where the products are mostly …

Purdue Ontology for Pharmaceutical Engineering

21 Jan. 2008 | Series | Contributor(s): Leaelaf Hailemariam, Venkat Venkatasubramanian, Shuo-Huan Hsu, Pradeep Suresh

Web Ontology Language (OWL), recommended by and based from Resource Description Framework (W3C), is used to define ontologies. OWL uses XML syntax to express semantics. OWL can formalize a domain by defining classes, properties of these classes, and relations between them. OWL can also define …

Navigating the POPE Ontology

21 Jan. 2008 | Teaching Materials | Contributor(s): Leaelaf Hailemariam, Venkat Venkatasubramanian

What knowledge is included in POPE? There are three knowledge components: guideline knowledge, mathematical knowledge and information representations. The guideline knowledge component includes representations of actions and decisions. The mathematical knowledge component includes descriptions of …

Roller Compaction Model

02 Jan. 2008 | Tools | Contributor(s): Kamal Kuriyan

Normal stresses for roller compaction are calculated from Johansons rolling theory.

Dynamic Roller Compactor

02 Jan. 2008 | Tools | Contributor(s): Shuo-Huan Hsu, Kamal Kuriyan, Nicholas Kisseberth

Dynamic simulation of roller compaction for dry granulation

Rotating Drum

07 Jan. 2008 | Tools | Contributor(s): Avik Sarkar, Carl Wassgren, dsk  

Simulation of particle flow in a rotating drum using discrete element methods

Particle Adhesion

07 Jan. 2008 | Tools | Contributor(s): Stephen Beaudoin, dsk  , Ravi Jaiswal, Caitlin Kilroy

The van der Waals adhesion force between a particle and a substrate in a given medium is simulated for a specified number of interactions.

Hopper Flow Discharge

07 Jan. 2008 | Tools | Contributor(s): dsk  , Avik Sarkar, Carl Wassgren

DEM simulation of the discharge of particles from a hopper

High Shear Mixer

07 Jan. 2008 | Tools | Contributor(s): dsk  , Avik Sarkar, Carl Wassgren

DEM simulation of particles as they move through a high shear mixer

ParticleVis: A Tool for DEM Particle Visualization

07 Jan. 2008 | Downloads | Contributor(s): Carl Wassgren, Avik Sarkar

ParticleVis is a visualization tool specialized for loading and exploring particulate simulation data. It contains a set of features that enables powerful and useful visualizations of particle simulations to be quickly generated. Support is provided for visualization of hundreds of thousands of …

Ontological informatics infrastructure for pharmaceutical product development

16 Jan. 2008 | Publications | Contributor(s): Venkat Venkatasubramanian, Rex Reklaitis, Leaelaf Hailemariam, Pradeep Suresh

Informatics infrastructure plays a crucial role in supporting different decision making activities related to pharmaceutical product development, pilot plant and commercial scale manufacturing by streamlining information gathering, data integration, model development and managing all these for easy …

SWOOP : Browsing the Product Formulation Ontology

16 Jan. 2008 | Tools | Contributor(s): dsk  , Leaelaf Hailemariam, Shuo-Huan Hsu, Pradeep Suresh

SWOOP is a hypermedia tool for browsing and developing ontologies -- with a web-browser look and feel

Towards intelligent decision support for pharmaceutical product development

16 Jan. 2008 | Publications | Contributor(s): Venkat Venkatasubramanian, Rex Reklaitis, Leaelaf Hailemariam, Pradeep Suresh

Developing pharmaceutical product formulation in a timely manner and ensuring quality is a complex process that requires a systematic, science-based approach. Information from various categories, including properties of the drug substance and excipients, interactions between materials, unit …

Computational Methods for Molecular Crystals

11 Sep. 2008 | Courses | Contributor(s): Stephan X.M. Boerrigter

This course that was designed for graduate students that are rounding up their course work and consider applying computational methods on molecular crystals as part of their PhD research. The lectures cover a wide range of theoretical topics including crystallography, ab initio quantum mechanics, …