Pharmacokinetic based design of individualized dosage regimens

10 May 2011 | Teaching Materials | Contributor(s): Jose Miguel Lainez, Gary Blau, Linas Mockus, Seza Orcun, Rex Reklaitis

Clinical trials and health care studies generate an enormous amount of data. This data is used by pharmaceutical companies during new drug development processes to characterize patient populations and determine a standardized dosage regimen for new patients. Nevertheless, the knowledge embedded...

pharmaHUB-PK

21 Nov 2011 | Tools | Contributor(s): Stephen Dion Stamatis, Michael McLennan, Lee Kirsch

Pharmacokinetic simulator

Preliminary Design Space

28 Oct 2010 | Online Presentations | Contributor(s): Linas Mockus

Probability Theory Review

05 May 2008 | Teaching Materials | Contributor(s): Gary Blau

For any real system or phenomenon, there will be a certain amount of variability associated with data generated by the system.Probability is the language used to characterize and interpret the variability of this data.Probability is the most widely used formalism for quantifying uncertainty.

Problems for Statistical Model Building

05 May 2008 | Teaching Materials | Contributor(s): Gary Blau

Scenarios, problem statements, JMP data files, and solutions for the course on Statistical Model Building and Design of Experiments. Scenario 1 is based on a batch reactor system for small molecule API production. Scenario 2 is based on a test-bed to study the feasibility of continuous operation...

Product Formulation

23 Jan 2008 | Online Presentations | Contributor(s): venkat, laelaf, pradeepsuresh

Pharmaceutical product development involves drug discovery,development of the drug substance (for improved processibility and absorption), anddevelopment of the drug product (identity and amount of excipients, choice of manufacturing platform or process).Product development requires access to...

Progress in Vacuum Pressure Measurement

08 Nov 2018 | Online Presentations | Contributor(s): Martin Wuest

For many years standard vacuum pressure measurement sensors consist of capacitance diaphragm gauges, Pirani heat transfer gauges as well as ionization gauges. Development has progressed from passive gauges with a detached controller to combination gauges with integrated electronics. Market...

PSL DEM Lecture 01: Motivation

26 Jan 2008 | Teaching Materials | Contributor(s): Carl Wassgren, Avik Sarkar

The Particulate Systems Laboratory at Purdue University presents the Discrete Element Modeling (DEM) Short Course Series. This is Lecture 01: Motivation.

PSL DEM Lecture 02: Hard Particle Collision Modeling

26 Jan 2008 | Teaching Materials | Contributor(s): Carl Wassgren, Avik Sarkar

The Particulate Systems Laboratory at Purdue University presents the Discrete Element Modeling (DEM) Short Course Series. This is Lecture 02: Hard Particle Collision Modeling

PSL DEM Lecture 03: Hard Particle Contact Detection

26 Jan 2008 | Teaching Materials | Contributor(s): Carl Wassgren, Avik Sarkar

The Particulate Systems Laboratory at Purdue University presents the Discrete Element Modeling (DEM) Short Course Series. This is Lecture 03: Hard Particle Contact Detection.

PSL DEM Lecture 06: Introduction to Soft-Particle DEM and Normal Contact Force Models - Part I

26 Jan 2008 | Teaching Materials | Contributor(s): Carl Wassgren, Avik Sarkar

The Particulate Systems Laboratory at Purdue University presents the Discrete Element Modeling (DEM) Short Course Series. This is Lecture 06: Introduction to Soft-Particle DEM and Normal Contact Force Models - Part I.

PSL DEM Lecture 07: Normal Contact Force Models - Part II

26 Jan 2008 | Teaching Materials | Contributor(s): Carl Wassgren, Avik Sarkar

The Particulate Systems Laboratory at Purdue University presents the Discrete Element Modeling (DEM) Short Course Series. This is Lecture 07: Normal Contact Force Models - Part II.

PSL DEM Lecture 09: Tangential Contact Force Models

15 May 2008 | Teaching Materials

The Particulate Systems Laboratory at Purdue University presents the Discrete Element Modeling (DEM) Short Course Series. This is Lecture 9: Tangential Contact Force Models.

PSL DEM Lecture 11: Coarse Contact Detection

15 May 2008 | Teaching Materials | Contributor(s): Carl Wassgren, Avik Sarkar

The Particulate Systems Laboratory at Purdue University presents the Discrete Element Modeling (DEM) Short Course Series. This is Lecture 11: Coarse Contact Detection.

PSL DEM Lecture 13: 3D Rotations

26 Jan 2008 | Teaching Materials | Contributor(s): Carl Wassgren, Avik Sarkar

The Particulate Systems Laboratory at Purdue University presents the Discrete Element Modeling (DEM) Short Course Series. This is Lecture 13: 3D Rotations.

Purdue Ontology for Pharmaceutical Engineering

21 Jan 2008 | Series | Contributor(s): laelaf, venkat, shsu, pradeepsuresh

Web Ontology Language (OWL), recommended by and based from Resource Description Framework (W3C), is used to define ontologies. OWL uses XML syntax to express semantics. OWL can formalize a domain by defining classes, properties of these classes, and relations between them. OWL can also define...

Raman Spectra Analyzer

05 Nov 2011 | Tools | Contributor(s): Linas Mockus

Raman Spectra Analyzer

Recommended Best Practices for Process Instrumentation in Freeze Drying

28 Jan 2019 | Online Presentations | Contributor(s): Steven L Nail

Response Surface Methodology

05 May 2008 | Teaching Materials | Contributor(s): Gary Blau

This lecture describes response surface models:Models are simple polynomialsInclude terms for interaction and curvatureCoefficients are usually established by regression analysis with a computer programInsignificant terms are discarded

Review of Statistics

05 May 2008 | Teaching Materials | Contributor(s): Gary Blau

This lecture covers the following topicsDifference between statistics and probabilityStatistical InferenceSamples and populationsIntro to JMP software packageCentral limit theoremConfidence intervalsHypothesis testingRegression and modeling fundamentalsIntroduction to Model BuildingSimple linear...