This is one of a set of experiments designed for lower level undergraduate courses. The focus of the experimental set is to introduce pharmaceutical concepts to undergraduates while also incorporating general engineering educational objectives. This contains both a student version and instructor version. In this lab, students work with Sheets™ brand energy strips, containing caffeine and blue food dye. Blue food dye in the product is used to model the release of a pharmaceutical ingredient. The students are to investigate the effect of temperature on the dissolution rate by placing one strip in water kept at room temperature (~ 22 °C), and placing another in water at body temperature (~ 37 °C). To simulate the mouth, a shallow petri dish is filled with 25 mL of water, in which a strip is placed. Absorbance measurements are taken at regular intervals, and graphs are generated. The objectives of this experiment are: Students will learn about mass transfer and degradation rates of drug delivery films; students will learn how to properly operate a spectrophotometer; students will determine the effect of temperature on this process. This experiment (and the others in this set) were developed by Rowan University as part of the NSF-funded Engineering Research Center (ERC) for Structured Organic Particulate Systems (SOPS).
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