You are here: resources › Tools › Lyo Calculator › About

Lyo Calculator

By Stan Karpuk1, Linas Mockus1, Alina Alexeenko1

1. Purdue University

Predict product temperature during primary drying

Launch Tool

This tool version is unpublished and cannot be run. If you would like to have this version staged, you can put a request through HUB Support.

Archive Version 1.3
Published on 24 Jul 2015
Latest version: 2.0. All versions

Open source: license | download

Category

Tools

Published on

Abstract

Predicts product temperature at the sublimation interface based on pseudo steady-state heat and mass transfer model

INPUT PARAMETERS:
Fill volume Solids concentration Shelf heat transfer coefficient Cross sectional area of the product in the vial Vial area calculated based on outside diameter Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thiskness of dry layer at any time Shelf temperature Chamber pressure OUTPUT: Temperature versus time chart

Cite this work

Researchers should cite this work as follows:

  • Stan Karpuk; Linas Mockus; Alina Alexeenko (2018), "Lyo Calculator," https://pharmahub.org/resources/lyocalculator.

    BibTex | EndNote

Tags

  1. freeze-drying
  2. Heat and mass transfer
  3. lyo
  4. lyocalculator
  5. Lyophilization
  6. Primary drying