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Lyo Calculator

By Linas Mockus

Purdue University

Predict product temperature during primary drying

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Archive Version 1.2
Published on 23 Jun 2014
Latest version: 2.0. All versions

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Predicts product temperature at the sublimation interface based on pseudo steady-state heat and mass transfer model

Fill volume Solids concentration Shelf heat transfer coefficient Cross sectional area of the product in the vial Vial area calculated based on outside diameter Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thiskness of dry layer at any time Shelf temperature Chamber pressure OUTPUT: Temperature versus time chart


M.J. Pikal Excel based Lyo Calculator


M.J. Pikal, Use of Laboratory Data in Freeze Drying Process Design: Heat and Mass Transfer Coefficients and the Computer Simulation of Freeze Drying

Cite this work

Researchers should cite this work as follows:

  • Linas Mockus (2018), "Lyo Calculator,"

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