This tool version is unpublished and cannot be run. If you would like to have this version staged, you can put a request through HUB Support.
You are here: resources › Tools › Lyo Calculator › About
Lyo Calculator
Predict product temperature during primary drying
Category
Published on
Abstract
Predicts product temperature at the sublimation interface based on pseudo steady-state heat and mass transfer model
INPUT PARAMETERS:
Fill volume Solids concentration Shelf heat transfer coefficient Cross sectional area of the product in the vial Vial area calculated based on outside diameter Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thiskness of dry layer at any time Shelf temperature Chamber pressure OUTPUT: Temperature versus time chart
INPUT PARAMETERS:
Fill volume Solids concentration Shelf heat transfer coefficient Cross sectional area of the product in the vial Vial area calculated based on outside diameter Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thiskness of dry layer at any time Shelf temperature Chamber pressure OUTPUT: Temperature versus time chart
Credits
M.J. Pikal Excel based Lyo Calculator
References
M.J. Pikal, Use of Laboratory Data in Freeze Drying Process Design: Heat and Mass Transfer Coefficients and the Computer Simulation of Freeze Drying
Cite this work
Researchers should cite this work as follows: