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  1. Towards intelligent decision support for pharmaceutical product development

    17 Jan 2008 | Publications | Contributor(s): Venkat Venkatasubramanian, Rex Reklaitis, Leaelaf Hailemariam, Pradeep Suresh

    Developing pharmaceutical product formulation in a timely manner and ensuring quality is a complex process that requires a systematic, science-based approach. Information from various categories, including properties of the drug substance and excipients, interactions between materials, unit...

  2. Simulation of the Adhesion of Particles to Surfaces

    20 Dec 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    The removal of micrometer and submicrometer particles fromdielectric and metal films represents a challenge in postchemicalmechanical polishing cleaning. Proper modeling of the adhesiveforce between contaminant particles and these films is needed todevelop optimal solutions to postchemical...

  3. Hamaker Constants in Integrated Circuit Metallization

    20 Dec 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    A new method for determining Hamaker constants was examinedfor materials of interest in integrated circuit manufacture. Anultra-high vacuum atomic force microscope and an atomic force microscopeoperated in a nitrogen environment were used to measurethe interaction forces between metals,...

  4. A Theoretical and Experimental Study of Surface Forces in Adhesion of Particles to Thin Films

    20 Dec 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    The interactions between micron- and nano-particles and rough surfaces are of great importance and have numerous applications in surface science and biotechnology. It is essential to have estimates of surface/intermolecular forces between interacting bodies to describe and to manipulate the...

  5. Roughness models for particle adhesion

    20 Dec 2007 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    The effects of different surface roughness models on a previously developed van der Waals adhesion model were examined. The van der Waals adhesion model represented surface roughness with a distribution of asperities. It was found that the constraints used todefine the asperity distribution on...

  6. Navigating the POPE Ontology

    21 Jan 2008 | Publications | Contributor(s): Leaelaf Hailemariam, Venkat Venkatasubramanian

    What knowledge is included in POPE? There are three knowledge components: guideline knowledge, mathematical knowledge and information representations. The guideline knowledge component includes representations of actions and decisions. The mathematical knowledge component includes descriptions...

  7. Ontological informatics infrastructure for pharmaceutical product development

    17 Jan 2008 | Publications | Contributor(s): Venkat Venkatasubramanian, Rex Reklaitis, Leaelaf Hailemariam, Pradeep Suresh

    Informatics infrastructure plays a crucial role in supporting different decision making activities related to pharmaceutical product development, pilot plant and commercial scale manufacturing by streamlining information gathering, data integration, model development and managing all these for...

  8. Drop formation: Methods and applications

    09 Sep 2008 | Publications | Contributor(s): Pradeep P. Bhat

    It is our common experience to see water drip out of a leaky faucet in, say, a kitchen sink. While dripping in this case may be an unwanted process, it can gainfully be employed as one of the methods, among a host of different techniques, to produce drops of various liquids for useful purposes....

  9. Discussion on Hamaker Constant

    09 May 2008 | Publications | Contributor(s): Stephen Beaudoin, Ravi Jaiswal, Caitlin Kilroy

    The Hamaker constant is a force constant used for describing the van der Waals (vdW) force. The magnitude of the Hamaker constant reflects the strength of the vdW force between two particles, or between a particle and a substrate. It depends on the material properties of both the interacting...

  10. Dynamic Simulation of Roller Compaction

    12 May 2008 | Publications | Contributor(s): Shuo-Huan Hsu

    A dynamic model for roller compaction process is derived based on Johanson’s rolling theory and material balance. Johanson’s rolling theory is used to predict the stress and density profiles during the compaction and the material balance equation describes the roll gap change. The proposed model...