Support

Trouble Report

For immediate assistance browse through our support center. You can find answers to many questions in just a few minutes.

If still experiencing problems, send us a report.

required
Why the math question?

Online Simulation

And More

  1. Knowledge-based systems
  2. Discrete element model (DEM)
  3. Particle adhesion
  4. Van der waals force
  5. Hamaker constants
  6. Process modeling
  7. Particle-based computations
  8. Molecular modeling
  9. Johanson's model
  10. Roller compaction
  11. Statistical model building
  12. Dry granulation
  13. Visualization
  14. Active pharmaceutical ingredient (API)
  15. Surface roughness
  16. Fast fourier transform
  17. Crystal graph

Other

0 Citation(s)

0 questions (Ask a question)

0 review(s) (Review this)

Level Set Dissolution

By Ann Christine Catlin1, Dan Braido2, Alberto Cuitino2

1. Purdue University; 2. Rutgers University;

Level Set Dissolution Description

Launch Tool

You must login before you can run this tool.

Version 1.0 - published on 17 Sep 2008

This tool is closed source.

View All Supporting Documents

See also

No results found.

Description

This tool takes a set of user defined parameters to build a model tablet and then simulate its dissolution. The simulation is based on several levels of tablet fluid interaction. This is accomplished via a series of equations which describe the surface erosion, solvent penetration, particle dissolution and solute diffusion. These equations are mostly based on a modified version of Fick's second law and are calculated using a finite-differencing scheme. The simulation space is mapped using a fixed cartesian mesh. The location of the tablets surface is tracked using a level set approach. The proper boundary conditions are applied to the diffusion equations using a concentration ghosting method.

cylinder

credits

Dan Braido
Alberto Cuitino

Cite this work

Researchers should cite this work as follows:

  • Dan Braido; Alberto Cuitino; Ann Christine Catlin (2008), "Level Set Dissolution," http://pharmahub.org/resources/levsetdissol.

    BibTex | EndNote

Tags
  1. Disintegration
  2. Dissolution
  3. Finite differencing
  4. Level sets

Supporting Documents